Detection of lung adenocarcinoma with ROSI rearrangement by IHC,FISH,and RT-PCR and analysis of its clinicopathologic features
Bing cao, Ping Wei, Zebing liu, et al.

To detect  ROS1  rearrangement  using  three  different  assays,  including  immunohistochemistry (IHC), fluorescence in situ
hybridization (FISH), and reverse transcription  polymerase chain reaction (RT-PCR), and to analyze the clinicopathologic
features of ROS1 rearrangement in patients with lung adenocarcinoma.

OncoTargets and Therapy, 2016:9 131-138

非小細胞肺癌組織中ALK、ROS1和RET融合基因的表達及其臨床意義
鐘山,張海萍,白冬雨等

探討非小細胞肺癌組織中ALK、ROS1和RET融合基因的表達情況及其與臨床病理特征的關系。
 

中華病理學雜志 2015年9月第44卷第9期(Chin J Pathol, September 2015 .Vol.44, No.9)

非小細胞肺癌患者EML4-ALK融合基因突變研究
王旭洲,陳煒生,余英豪

非小細胞肺癌(non-small cell lung cancer, NSCLC)是肺癌的主要類型,相關位點突變檢 測研究已經成為肺癌分子靶向治療的熱門方向,研究NSCLC腫瘤組織中動物微管相關蛋白4與間變性淋巴瘤激酶融合基因(echinodem microtubule associated protein like 4-
Anaplastic lymphoma kinase, EML4-ALK)與表皮生長因子受體(epidermal growth factor receptor, EGFR)的基因突變狀態,比較免疫組織化學(immunohistochemistry, IHC)與蝎形探針擴增阻滯突變系統(Scorpions amplification refractory mutation system, Scorpions ARMS)熒光定量PCR與熒光原位雜交(fluorescence in situ hybridization, FISH)檢測EML4-ALK融合基因與EGFR基因突變的敏感性。

中國肺癌雜志 2015年2月第18卷第2期(Chin J Lung Cancer, February 2015, Vol.18, No.2)

Molecular spectrum of KRAS,NRAS,BRAF and PIK3CA mutations in Chinese colorectal cancer patients_analysis of 1,110 cases
Jing Zhang, Jianming Zheng, Yinghong Yang, et al.

Mutations in genes such as KRAS, NRAS, BRAF and PIK3CA have become an important part of colorectal carcinoma evaluation. The aim of this study was to screen for mutations in these genes in Chinese patients with colorectal cancer (CRC) and to
explore their correlations with certain clinicopathological parameters. We tested mutations in the KRAS (exons 2, 3 and 4),
NRAS (exons 2, 3 and 4), PIK3CA (exon 20) and BRAF (exon 15) genes using reverse transcriptase-polymerase chain reaction
(RT-PCR) and Sanger sequencing in a large cohort of 1,110 Chinese CRC patients who underwent surgical resection at one of
three major teaching hospitals located in different regions of China.

Scientific RepoRts | 22 December 2015 | 5:18678 | DOI: 10.1038/srep18678

Value of TIRADS, BSRTC and FNA-BRAFV600E mutation analysis in differentiating high-risk thyroid nodules(Scientific Reports)
Yu-zhi Zhang, Ting Xu, Dai Cui, et al.

The thyroid imaging reporting and data system (TIRADS) and Bethesda system for reporting thyroid cytopathology (BSRTC)
have been used for interpretation of ultrasound and fine-needle aspiration cytology (FNAC) results of thyroid nodules.
BRAFV 600E mutation analysis is a molecular tool in diagnosing thyroid carcinoma. Our objective was to compare the
diagnostic value of these methods in differentiating high-risk thyroid nodules. Total 220 patients with high-risk thyroid
nodules were recruited in this prospective study.

Scientific Reports | 24 November 2015 | 5:16927 | DOI: 10.1038/srep16927

Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma
Weijing Cai, Dongmei Lin, Chunyan Wu, et al.

Genetic intratumoral heterogeneity has a profound influence on the selection of clinical treatment strategies and on
addressing resistance to targeted therapy. The purpose of this study was to explore the potential effect of intratumoral
heterogeneity on both genetic and pathologic characteristics of ALK-rearranged lung adenocarcinoma (LADC).

J Clin Oncol. 2015 November 10; 33(32): 3701–3709. doi:10.1200/JCO.2014.58.8293.

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